I feel the glass doorknobs are a historic part of the building that should remain in place. Any good woodworker can easily fill in deadbolt holes and re-paint the doors if a future owner wants to convert the place back to a private historic residence.
As Copperhead mentioned, the
keyless deadbolts are really nice, because you don't have to worry with people carrying off or losing your keys, or copying them. Also, each person in the room can know the code so you don't have to give out multiple keys. You give guests a 4-digit code to unlock their door, and it's easy to change the code when they leave.
The deadbolts are available in a variety of finishes and cost about $100, which isn't a lot more than you'd be paying for keyed deadbolts. The ones for my place are wireless so I can delete old entry codes and program new ones from my computer, so they cost a little more than the manual ones.
As you see from the photo below, they can also be operated with a key, so you can still open the door if the keypad fails (like if the battery runs down...but they last about 2 years). You don't give the key to the guests. It's just for you.